{"id":492,"date":"2024-07-30T12:43:10","date_gmt":"2024-07-30T12:43:10","guid":{"rendered":"https:\/\/exciting-elbakyan.137-74-93-36.plesk.page\/?page_id=492"},"modified":"2026-03-27T12:07:51","modified_gmt":"2026-03-27T12:07:51","slug":"pipeline","status":"publish","type":"page","link":"https:\/\/exciting-elbakyan.137-74-93-36.plesk.page\/index.php\/pipeline\/","title":{"rendered":"Pipeline y evoluci\u00f3n ensayos cl\u00ednicos"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"492\" class=\"elementor elementor-492\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5c30e60 e-flex e-con-boxed e-con e-parent\" data-id=\"5c30e60\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-368bbdb e-con-full e-flex e-con e-child\" data-id=\"368bbdb\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c0bae75 elementor-widget__width-initial elementor-absolute ha-has-bg-overlay elementor-widget elementor-widget-spacer\" data-id=\"c0bae75\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec8fca3 elementor-widget elementor-widget-heading\" data-id=\"ec8fca3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Investigaci\u00f3n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-15b8307 elementor-widget elementor-widget-heading\" data-id=\"15b8307\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">PIPELINE Y EVOLUCI\u00d3N DE ENSAYOS CL\u00cdNICOS<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30a64f16 elementor-widget elementor-widget-text-editor\" data-id=\"30a64f16\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">La INVESTIGACI\u00d3N es nuestra esperanza para encontrar una cura o tratamiento, o al menos mejorar la calidad de vida de los pacientes con ataxia telangiectasia.<\/span><\/p><p><span style=\"font-weight: 400;\">El siguiente gr\u00e1fico muestra el progreso de los diferentes ensayos cl\u00ednicos que se est\u00e1n desarrollando actualmente, as\u00ed como tambi\u00e9n, el avance hacia nuevos tratamientos en algunos de los proyectos m\u00e1s relevantes.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6963b1a elementor-widget__width-inherit ha-has-bg-overlay elementor-widget elementor-widget-html\" data-id=\"6963b1a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div style=\"width:100%; height:75vh; overflow:auto; background:#fff; text-align:center;\">\n  <iframe\n    src=\"https:\/\/exciting-elbakyan.137-74-93-36.plesk.page\/wp-content\/uploads\/2026\/03\/pipeline-_1_.html\"\n    style=\"\n      width:900px;\n      height:430px;\n      border:none;\n      zoom:1.45;\n      display:block;\n      margin:0 auto;\n      background:#fff;\n    \">\n  <\/iframe>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f13803a elementor-widget elementor-widget-text-editor\" data-id=\"f13803a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">En general, la investigaci\u00f3n para desarrollar un tratamiento pasa por varias fases, cada una esencial para garantizar su seguridad y eficacia:<\/span><\/p><p><b>Investigaci\u00f3n b\u00e1sica y precl\u00ednica<\/b><span style=\"font-weight: 400;\">: Se realizan estudios en laboratorio para entender la enfermedad y encontrar posibles mol\u00e9culas o compuestos que puedan tratarla. Luego, los candidatos m\u00e1s prometedores se prueban en modelos animales para evaluar su seguridad y efectividad inicial.<\/span><\/p><p><b>Ensayos cl\u00ednicos (Fase I, II y III):<\/b><\/p><p><b>Fase I<\/b><span style=\"font-weight: 400;\">: Se prueba el tratamiento en un peque\u00f1o grupo de voluntarios sanos o pacientes, evaluando su seguridad, dosis adecuada y posibles efectos secundarios.<\/span><\/p><p><b>Fase II<\/b><span style=\"font-weight: 400;\">: Se ampl\u00eda el estudio a un grupo mayor de pacientes para determinar su eficacia y continuar evaluando la seguridad.<\/span><\/p><p><b>Fase III<\/b><span style=\"font-weight: 400;\">: Se realizan estudios a gran escala con cientos o miles de pacientes, si los hubiera, para confirmar su eficacia, monitorear efectos adversos y compararlo con tratamientos existentes.<\/span><\/p><p><b>Evaluaci\u00f3n y aprobaci\u00f3n regulatoria<\/b><span style=\"font-weight: 400;\">: Los resultados de los ensayos cl\u00ednicos se presentan a agencias regulatorias (como la FDA y EMA), que revisan toda la evidencia cient\u00edfica para decidir si el tratamiento puede ser aprobado para su uso en el mercado.<\/span><\/p><p><b>Producci\u00f3n y comercializaci\u00f3n<\/b><span style=\"font-weight: 400;\">: Una vez aprobado, se inicia la producci\u00f3n a gran escala y se lanza al mercado, asegurando su distribuci\u00f3n. Adem\u00e1s, se contin\u00faa monitoreando su seguridad y eficacia en la poblaci\u00f3n general (<\/span><b>Fase IV, farmacovigilancia<\/b><span style=\"font-weight: 400;\">).<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4701040 e-flex e-con-boxed e-con e-parent\" data-id=\"4701040\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d8b1005 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-html\" data-id=\"d8b1005\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p style=\"text-align: justify;\"><img decoding=\"async\" src=\"https:\/\/exciting-elbakyan.137-74-93-36.plesk.page\/wp-content\/uploads\/2025\/02\/pipeline_aefat_ataxia_telangiectasia_English2.jpg\" usemap=\"#mapa1\"><map name=\"mapa1\"> \n<area alt=\"N-Acetyl L-Leucine\" coords=\"70,130,405,155\" shape=\"rect\" href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03759678?term=IntraBio\" target=\"_blank\" title=\"N-Acetyl L-Leucine\">\n \n<area alt=\"Intrabio, UK\" coords=\"550,130,900,155\" shape=\"rect\" href=\"https:\/\/intrabio.com\/431-2\/\" target=\"_blank\" title=\"Intrabio, UK\">\n \n<area alt=\"Nicotinamide Riboside (NAD+)\" coords=\"70,155,405,180\" shape=\"rect\" href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04870866?cond=Ataxia+Telangiectasia&amp;draw=2&amp;rank=2\" target=\"_blank\" title=\"Nicotinamide Riboside (NAD+)\">\n \n<area alt=\"Oslo University Hospital, Norway\" coords=\"550,155,900,180\" shape=\"rect\" href=\"https:\/\/www.med.uio.no\/klinmed\/english\/people\/aca\/hildni\/\" target=\"_blank\" title=\"Oslo University Hospital, Norway\">\n \n<area alt=\"Triheptanoin\" coords=\"70,180,450,205\" shape=\"rect\" href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04513002?cond=Ataxia+Telangiectasia&amp;draw=2&amp;rank=1\" target=\"_blank\" title=\"Triheptanoin\">\n \n<area alt=\"Queensland Children\u2019s Hospital Brisbane, Australia\" coords=\"550,180,900,205\" shape=\"rect\" href=\"https:\/\/www.researchgate.net\/profile\/David-Coman-2\" target=\"_blank\" title=\"Queensland Children\u2019s Hospital Brisbane, Australia\">\n \n<area alt=\"Intra-Erythrocyte Dexamethasone\" coords=\"70,205,500,230\" shape=\"rect\" href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03563053?cond=Ataxia+Telangiectasia&amp;draw=2&amp;rank=8\" target=\"_blank\" title=\"Intra-Erythrocyte Dexamethasone\">\n \n<area alt=\"Erydel, Italy\" coords=\"550,205,900,230\" shape=\"rect\" href=\"https:\/\/www.erydel.com\/home.php\" target=\"_blank\" title=\"Erydel, Italy\">\n \n<area alt=\"Hematopoietic stem cell transplant &amp; 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El siguiente gr\u00e1fico muestra el progreso de los diferentes ensayos cl\u00ednicos que se est\u00e1n desarrollando actualmente, as\u00ed como tambi\u00e9n, el avance hacia nuevos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-492","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pipeline y evoluci\u00f3n ensayos cl\u00ednicos - Aefat<\/title>\n<meta name=\"description\" content=\"La INVESTIGACI\u00d3N es nuestra esperanza para encontrar una cura o tratamiento, o al menos mejorar la calidad de vida de los pacientes con ataxia telangiectasia.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pipeline y evoluci\u00f3n ensayos cl\u00ednicos - 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